“Enhancers” of enhancers?

“Enhancers” of enhancers?

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I am looking for examples (if any) of genomic regions which regulates the activity of enhancers, either augmenting or reducing it. Essentially some kind of enhancers (or repressors) of enhancers to make a Russian doll analogy. I know about epigenetic markings but I am really looking at an example of a DNA region directly acting on a enhancer similar to an enhancer acting directly onto a promoter.

I am asking that because I couldn't find any examples and was wondering if I missed such a report/paper.

If you're looking for a strictly and directly DNA-DNA mediated effect (no histones, no transcription involved) I'd look for sequence effects on chromatin remodelling, modulating access of transcription factors (TFs) to their elements. Something about this might be in this paper: Szerlong, H. J., & Hansen, J. C. (2011). Nucleosome distribution and linker DNA: connecting nuclear function to dynamic chromatin structure. Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire, 89(1), 24-34. doi:10.1139/O10-139

Watch the video: Gene regulation in Eukaryotes. Promoters. Transcription factors. Enhancers. Genetics for beginners (May 2022).


  1. Mikagor

    Look, let's not waste any more time on this.

  2. Claegborne

    I cannot participate in the discussion now - no free time. Osvobozhus - make sure your opinion on this issue.

  3. Ranger

    Why does your resource have such a small number?

  4. Bardene

    This is the excellent idea

  5. Mular


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