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Can the Na+/K+ pump backwards to generate ATP?

Can the Na+/K+ pump backwards to generate ATP?


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The standard physiological direction of the Na+/K+ pump is to export 3 Na+, import 2 K+, and hydrolyze one ATP to ADP. Can it be driven backwards, importing 3 Na+, exporting 2 K+, and generating ATP? Does this happen in normal cells, and in what conditions?


All enzymes can theoretically catalyze the reverse reaction.

Researchers have driven the Na+/K+ ATPase to synthesize ATP with artificial ion concentrations:

We have studied the apparent affinity for K at its intracellular discharge sites by measuring the rate of ATP synthesis as a function of the internal K concentration in resealed red blood cell ghosts, where the Na-K pump is driven in reverse by the downhill efflux of K and influx of Na…


Watch the video: ΚΑΝΕ ΜΕ ΠΑΛΙ ΝΑ ΜΠΟΡΩ ΡΙΤΑ ΑΝΤΩΝΟΠΟΥΛΟΥ (July 2022).


Comments:

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  6. Alarick

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  7. Zujora

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  8. Harrell

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