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DrugBank from the University of Alberta
DrugBank: database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information
MOAD: Mother of All Databases - largest collection of well resolved protein crystal structures with clearly identified biologically relevant ligands annotated with experimentally determined binding data
extracted from literature
References
- Moellering, R. et al. Direct inhibition of the NOTCH transcription factor complex. Nature 462, 171 and 182 (2009)
- Keiser, M. Predicting new molecular targets for known drugs. Nature 462, 167 and 175 (2009)
- Oh, P. Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature. 429, pg 629 (2004)
- Dumoulin, M. A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. Nature, 424, pg 783 (2003).
- Huang, D. Crystal structure of NF-κB (p50)2 complexed to a high affinity RNA aptamer. Proc. Natl. Acad. Sci. USA. 100, pg 9268 (2003)
- Sanchez, I. Pivotal Role of oligomerization in expanced polyglutamine neurodegenerative disorders. 421, pg 373, (2003)
- Hammarstrom, P. Prevention of Transthyretin Amyloid Disease by changing protein misfolding energetics. Science. 299, pg 713 (2003)
- Rusconi, C. RNA apatmaers as reversible antagonists of coagulation factor IXA. 419, pg 90, 23 (2002)
- Zasloff. Antimicorbial peptides of multicellular organisms. 415, pg 389 (2002)
- RNA Interference: The Short Answer (blocking mRNA). 411 pg 428 (2001)
- Fernandez-Lopez et al. Rings of Destruction. (Cyclic peptides as drugs). Natuare. 412 pg 392, 452 (2001)
- Small but mighty timekeepers. (small RNA inhibition of translation) Nautre. 408, pg 37 (2000)
- Shokat et al. A Chemistry Set for Life. (Chemical genetics: inhibitors designed for specific gene products)*** Nature 407, pg 282, 395 (2000)
- Clark et al. Molecular Switches in Metastasis. 406. pg 466, 532 (2000)
- Root et al. Protein Design of an HIV-1 Entry Inhibitor. 291, pg 884 (2001)
- Tyler et al. Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression . PNAS, Vol. 96, Issue 12, 7053-7058, June 8, 1999.
- Interfering with Gene Expression (silencing at the mRNA level). 288, pg 1370 (2000)
- Gellman et al. Slaying Bacteria with β-peptides. 404, pg 565 (2000)
- RNA interference (RNAi by short RNAs that demonstrate transcriptional silencing). 287, pg 2431, 2494 (2000)
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- Kiessling, L et al. Synthetic multivalent ligands in the exploration of cell-surface Current Opinion in Chemical Biology, 4, pg696 (2000)
